{"id":2,"url":"https://cclm.media-doc.io/conditions/2/","name":"Acanthamoeba Infection","category":"Cornea","detail":"<p>Protozoan infection of the cornea</p>\n\n<h2>Symptoms</h2>\n\n<ul>\n\t<li>Intense pain, generally out of proportion to associated signs</li>\n\t<li>Photophobia</li>\n\t<li>Long, tortuous course of presentation of varying intensity</li>\n</ul>\n\n<h2>Signs</h2>\n\n<ul>\n\t<li>Initially presents as a central to paracentral localized haze</li>\n\t<li>Presence of cysts or trophozoites within the stroma shown by confocal microscopy</li>\n\t<li>Ring infiltrate occurs as the condition advances</li>\n\t<li>Poor response to topical therapy</li>\n</ul>\n\n<h2>Etiology</h2>\n\n<ul>\n\t<li><em>Acanthamoeba</em>&nbsp;is a ubiquitous free-living protozoan</li>\n\t<li>Use of unpreserved solutions, tap water, fresh water or poor hygiene</li>\n\t<li>Aggressive infection of the cornea</li>\n\t<li>The cyst form of this organism accounts for its resistance to treatment</li>\n</ul>\n\n<h2>Prevalence</h2>\n\n<ul>\n\t<li>Rare</li>\n</ul>\n\n<h2>Differential Diagnosis</h2>\n\n<ul>\n\t<li>Herpes simplex keratitis</li>\n\t<li>See: <a href=\"/condition/66\">Infiltrates and Opacities &ndash; Differential Diagnosis</a></li>\n\t<li>Erosion</li>\n</ul>\n\n<h2>Management</h2>\n\n<ul>\n\t<li>Early diagnosis and treatment by a corneal specialist is essential.</li>\n\t<li>Avoidance is preferable. Avoid unpreserved saline, tap water or other unpreserved solutions, exposure to hot-tubs, and stagnant fresh-water ponds.</li>\n\t<li>Replace lens storage case regularly to avoid biofilm buildup; avoid using tap-water to rinse case.</li>\n\t<li>Treatment with a combination of anti-amoebic and trophozoicidal drugs [eg, propamidine, neomycin and 0.02% polyhexammethylene-biguanide (PHMB)].</li>\n\t<li>To minimize risk, consider DD lenses.</li>\n</ul>","images":[{"name":"Acanthamoeba Infection","file":"https://cclm-static.s3.amazonaws.com/images/acanthamoeba_zoom.jpg"}],"type":1,"videos":[],"wear":false,"ceaseWear":true,"changeLens":false,"changeSolutions":false,"changeCare":false,"counseling":true,"dd":true,"dw":false,"gp":false,"replace":false,"review":true,"rewettingDrops":false,"rx":true,"SiHy":false,"toric":false,"tags":[]}