{"id":20,"url":"https://cclm.media-doc.io/conditions/20/","name":"Infiltrates – Infiltrative Keratitis","category":"Cornea","detail":"<p>Marginal keratitis, asymptomatic infiltrative keratitis, marginal infiltrate, sterile infiltration</p>\n\n<h2>Symptoms</h2>\n\n<ul>\n\t<li>Minor infiltrates may be asymptomatic</li>\n\t<li>Discomfort, foreign body sensation</li>\n\t<li>Redness</li>\n\t<li>Mild photophobia</li>\n\t<li>Symptoms reduce on lens removal</li>\n</ul>\n\n<h2>Signs</h2>\n\n<ul>\n\t<li>Single or multiple circular infiltrates in epithelium or anterior stroma</li>\n\t<li>May be unilateral or bilateral</li>\n\t<li>Localized bulbar and/or limbal hyperemia adjacent to infiltrates</li>\n\t<li>Overlying epithelium generally does not stain</li>\n</ul>\n\n<h2>Etiology</h2>\n\n<ul>\n\t<li>Inflammatory reaction resulting in accumulation of white blood cells in cornea</li>\n\t<li>Response to hypoxia, chemical toxicity, cellular debris, allergens, denatured protein, exotoxins and/or endotoxins from bacteria</li>\n</ul>\n\n<h2>Prevalence</h2>\n\n<ul>\n\t<li>Infrequent</li>\n</ul>\n\n<h2>Differential Diagnosis</h2>\n\n<ul>\n\t<li><a href=\"/condition/24\">Microbial keratitis</a></li>\n\t<li>Adenoviral infection</li>\n\t<li><a href=\"/condition/6\">CLPU</a></li>\n\t<li><a href=\"/condition/66\">See: Infiltrates and Opacities &ndash; Differential Diagnosis</a></li>\n</ul>\n\n<h2>Management</h2>\n\n<ul>\n\t<li>Remove cause of inflammatory response</li>\n\t<li>In severe cases, discontinue lens wear until infiltrate totally resolves</li>\n\t<li>Prophylactic antibiotic may be prescribed</li>\n\t<li>Mild steroid may be prescribed</li>\n\t<li>Treat blepharitis if present</li>\n\t<li>Review within 1 week. Resolution may require &gt; 2 weeks</li>\n\t<li>May change to DW, change to a higher Dk lens, increase lens replacement frequency (DD), change care system</li>\n</ul>","images":[{"name":"Infiltrates – Infiltrative Keratitis","file":"https://cclm-static.s3.amazonaws.com/images/infiltrates-keratitis_zoom.jpg"}],"type":1,"videos":[{"name":"Infiltrates (Central and Fine)","videoSrc":"248362050"},{"name":"Infiltrates (Diffuse and Peripheral)","videoSrc":"255934350"}],"wear":false,"ceaseWear":true,"changeLens":true,"changeSolutions":false,"changeCare":true,"counseling":false,"dd":false,"dw":false,"gp":false,"replace":false,"review":true,"rewettingDrops":false,"rx":false,"SiHy":true,"toric":false,"tags":[]}