{"id":28,"url":"https://cclm.media-doc.io/conditions/28/","name":"Polymegethism","category":"Cornea","detail":"<h2>Symptoms</h2>\n\n<ul>\n\t<li>None</li>\n</ul>\n\n<h2>Signs</h2>\n\n<ul>\n\t<li>Variation in cell size and cell shape (pleomorphism) of the endothelium; seen with high magnification (40x) in the endothelial specular reflection</li>\n</ul>\n\n<h2>Etiology</h2>\n\n<ul>\n\t<li>Thought to result from chronic hypoxia causing corneal acidosis following wear of lens with a low Dk/t</li>\n\t<li>Common in long-term wearers, especially of PMMA and low Dk/t hydrogel lenses</li>\n</ul>\n\n<h2>Prevalence</h2>\n\n<ul>\n\t<li>Rare with modern materials</li>\n</ul>\n\n<h2>Differential Diagnosis</h2>\n\n<ul>\n\t<li>Other&nbsp;<a href=\"/condition/62\">endothelial anomalies</a>&nbsp;and corneal dystrophies</li>\n\t<li>See: <a href=\"/condition/62\">Endothelial Changes &ndash; Differential Diagnosis</a></li>\n\t<li><a href=\"/condition/61\">Corneal Exhaustion Syndrome</a></li>\n</ul>\n\n<h2>Management</h2>\n\n<ul>\n\t<li>Refit with a lens of high Dk/t (SiHy), or change to DW / reduce wearing time</li>\n</ul>","images":[{"name":"Polymegethism","file":"https://cclm-static.s3.amazonaws.com/images/polymegethism_zoom.gif"}],"type":1,"videos":[],"wear":true,"ceaseWear":false,"changeLens":false,"changeSolutions":false,"changeCare":false,"counseling":false,"dd":false,"dw":true,"gp":false,"replace":false,"review":false,"rewettingDrops":false,"rx":false,"SiHy":true,"toric":false,"tags":[]}